Infectious diseases and systemic inflammatory response in paediatrics

Infectious diseases and systemic inflammatory response in paediatrics

  • Systemic inflammatory response in paediatric age

    Systemic inflammatory response in paediatric age

    The research is focused on the study of the immunologic mechanisms involved in primary and secondary immunodeficiencies, autoinflammatory diseases and paediatric systemic autoimmune diseases.

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  • HIV

    HIV

    Study of the factors associated with vertically transmitted infections and especially with HIV infection: long-term follow-up of healthy patients exposed to HIV and to anti-retroviral drugs to define whether exposure to such drugs in the gestational and neonatal periods affects neurologic or weight-height development in any way when associated with carcinogenesis, or if they are a risk factor for other disorders.

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  • Vaccine-preventable diseases

    Vaccine-preventable diseases

    The human species' first contact with many microorganisms takes place in childhood, when children have not been infected and have not developed the disease. Vaccination in early ages of life has proven to be an effective tool in the fight against infectious diseases. In order to evaluate the best vaccination strategies in a specific population, a good molecular characterisation of the microorganisms circulating in the respective community is essential since microorganisms diversify genetically to adapt themselves as well as possible to a specific environment.

    Our research is divided into two lines of action: (1) epidemiologic surveillance of vaccine-preventable diseases, and (2) diagnostic innovation.

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  • Tuberculosis

    Tuberculosis

    Research on the adherence and toxicity associated with first-line anti-tuberculosis drugs in the paediatric age, on the pharmacokinetic characteristics of these drugs on newborns and pre-school children, on the new tuberculosis diagnostic techniques in healthy children, on children from high tuberculosis endemic areas and on immunosuppressed children, and on the clinical-epidemiological characteristics of tuberculosis in childhood in our area.

     

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