Molecular and cellular biology of developmental tumours

Molecular and cellular biology of developmental tumours

  • Preclinical pharmacology and drug release in solid paediatrics tumours

    Preclinical pharmacology and drug release in solid paediatrics tumours

    Development of preclinical disease models (neuroblastoma, diffuse intrinsic pontine glioma/DIPG, rhabdomyosarcoma, Ewing's sarcoma, retinoblastoma) on the basis of biobank samples. Study of new treatments (pharmacological, biological and immunotherapy) in preclinical models of paediatric solid tumours. Study of the penetration of chemotherapeutic agents in preclinical models of paediatric solid tumours. Development of new chemotherapy release systems in paediatric solid tumours.

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  • Translational genomics

    Translational genomics

    Integration of the knowledge of the genome and of medicine to improve therapeutic strategies. The aim is to use "omics" technologies to identify the underlying molecular mechanisms of the biology and clinical-pathological behaviour of developmental tumours, as a possibility for the development of diagnostic, prognostic and treatment-response biomarkers.

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  • Leukaemia and non-malignant blood disorders

    Leukaemia and non-malignant blood disorders

    The primary goal is to deepen our understanding of the origin and molecular bases of paediatric haematological malignancies with a view to transferring new diagnostic, prognostic and therapeutic tools to clinical practice.  We seek to conduct translational and easily applicable research both on leukaemias and bone marrow failure syndromes, and on non-neoplastic blood changes, haemoglobin disorders and coagulation disorders.

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  • Neuroblastoma

    Neuroblastoma

    Our research group studies and identifies new therapeutic targets in neuroblastoma, and provides personalized treatment to pediatric patients affections of a refractory solid tumor relapsed / based on knowledge of their genetic alterations.

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  • Sarcoma and histiocytosis

    Sarcoma and histiocytosis

    The main areas of research are:

    • Study of the origin of sarcoma and phenotypic and genotypic characterisation of the various clinical subtypes.
    • Research on the existence of precursor or tumour stem cells.
    • Improved treatment of patients with sarcomas through the study of pre-clinical pharmacology.
    • Development of therapies targeted at the IgF1r pathway.
    • Study of directed therapies and molecular pathways in histiocytosis.
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