Paediatric Diseases originating in early life

Paediatric Diseases originating in early life

  • Metabolic endocrinology

    Metabolic endocrinology

    Foetal growth restriction may have irreversible consequences. The study of the various stages from intrauterine life to adolescence will allow us to advance in the prevention of this condition and in the treatment and prevention of the complications derived from it.

    • Prenatal diagnosis.
    • Postnatal growth restriction and prematurity.Influence of various nutritional inputs on catch-up in children with intrauterine growth retardation, on extreme prematures and on experimentation models.
    • Endocrinological and developmental effects.
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  • Neonatal physiopathology

    Neonatal physiopathology

    The genetic potential, the foetal environment and perinatal or neonatal aggressions in the neonatal period may have irreversible consequences for the individual's development and they may be the origin of permanent damage or disorders in the adult. The study of the factors and causes that have an influence during the intrauterine, perinatal and neonatal periods will allow us to increase our knowledge of the conditioning factors that may interfere with correct development. Moreover, the research on therapeutic interventions in the neonatal period, together with the follow-up of children at risk of development disorders and disability, will allow better treatments and preventive strategies to be implemented.

    Work is carried out in this line of research in four main areas:

    • Prematurity, development care and follow-up.
    • Growth, nutrition and metabolism.
    • Neonatal neurobiology.
    • Critical care.
    • Follow-up of newborns at risk.
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  • Childhood diabetes

    Childhood diabetes

    The hypothesis of the foetal origin of adult disorders postulates that an adverse intrauterine environment may affect the growth of the foetus by producing permanent changes of gene expression in key cells and/or tissues. Such changes would persist after birth and could contribute to the development of chronic and complex disorders typical of adults, such as type 2 diabetes or obesity. Our laboratory's goal is to understand the molecular mechanisms that associate nutrition during intrauterine development with the risk of acquiring chronic disorders as an adult, with special emphasis on diabetes and obesity.

    In order to understand the underlying molecular mechanisms, in our group we have developed an experimental model of foetal malnutrition that recapitulates the metabolic phenotype described in humans: malnourished mice in the uterus show low weight at birth and develop obesity, intolerance to glucose, and diabetes as from the 4th month of life.


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