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Research Groups

Systemic inflammatory response in paediatric age

None

Coordinators of the group

  • Jordi Antón López

The research is focused on the study of the immunologic mechanisms involved in primary and secondary immunodeficiencies, autoinflammatory diseases and paediatric systemic autoimmune diseases.

The various lines of work include the study of primary immunodeficiencies and especially those which are centred on innate immunity (Toll-IL-1R and IL-12/IFN-gamma pathways) and which explain part of the susceptibility to common infections in paediatrics; the study of paediatric common variable immunodeficiency; and the analysis of phenotypes and genotypes. Work is also carried out to improve the knowledge and management of secondary immunodeficiency in paediatric patients and in pregnant women (a research line on the effects on the newborn's immune system of treatment with anti-TNF alpha antibodies in expectant mothers with inflammatory bowel disease).

Other lines of work involve the study of autoinflammatory syndromes such as mevalonate kinase deficiency or hyper-IgD syndrome, cryopyrin-associated autoinflammatory syndrome (CAPS) or familial Mediterranean fever, and autoimmune diseases such as uveitis associated with juvenile idiopathic arthritis, juvenile dermatomyositis, and paediatric vasculitis disorders such as Kawasaki disease.

The goals of this group also include the identification of the genes causing disorders, the study of the involvement of epigenetics and the microbiome, and the recognition of pathogenic pathways, which will allow the development of new treatment proposals.

The group's approach is based on translational research, for which reason its lines of work are carried out at patients' side, striving to improve their quality of life. To this end the group has the close cooperation of other practitioners of Hospital Sant Joan de Déu Barcelona and of other prestigious national and international institutions.

The Study Group on Immune Dysfunction Disorders in Paediatrics (GEMDIP) has been recognised as an emerging research group by AQU Catalunya (Agency for the Quality of the University System of Catalonia).