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Research Groups

Molecular Psychiatry

Grup Belen Ramos 2017

Coordinators of the group

  • Belén Ramos Josemaria

The research focuses on investigating altered molecular mechanisms in the brain in schizophrenia that can lead to alterations in neuronal development or functioning of synaptic transmission, with special interest in transcription factors.

 

In addition, this group studies the relationship of these altered pathways with symptoms, cognitive functioning, structural changes in the brain and in response to therapeutic interventions. The ultimate goal is to find biomarkers at an early stage that will help us predict the evolution of symptoms and cognitive impairment, so that we can apply early interventions of greater efficacy.

Specific objectives:

  1. To identify new molecular pathways altered in the brain in chronic schizophrenia, especially those involved in neurodevelopment, synaptic function and/or gene expression regulators.
  2. To study components of these molecular pathways altered in the brain in schizophrenia in relation to symptoms and neuropsychological functioning in schizophrenia.
  3. To study molecular pathways altered in schizophrenia in cellular models and animals of psychosis.
  4. To study peripheral biomarkers in psychosis in relation to symptoms and cognitive functioning and in response to therapeutic interventions.
  5. To study peripheral biomarkers in first psychotic episodes in relation to changes in structural neuroimaging.