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Research groups

Molecular pharmacology and experimental therapies

2017_provisional_pastor

Coordinator: Marçal Pastor-Anglada

Our research group is studying diverse aspects of the cellular and molecular biology of membrane transporters, essentially in epithelial cells and in cells of the immune system. Two of the transporter gene families currently under study are CNT and ENT transporters responsible for the uptake of natural nucleosides and a wide range of drugs used in the treatment of cardiovascular diseases and antitumor therapies and antivirals.

Team

  • Researcher: Sandra Pérez Torras
  • Assistant researcher: Clara Boces Pascual, Aida Mata Ventosa, Catalina Perelló Reus
  • PhD Student: Albert Viel Oliva, Olga Casulleras Gras, Sandra Moro Villa, Hamsa Banjer, Liska Caviedes Cárdenas
  • Technician: Nerea Urtasun Plans, Ingrid Iglesias-Garanto

Selected projects

  • Disección funcional de las propiedades de las proteínas 'human concentrative nucleoside transporter' (hCNT). Ministerio de Economia y Competitividad. PI: Marçal Pastor Anglada. January 2015 – December 2017
  • Papel del miRNoma tumoral en la expresión de transportadores de membrana implicados en el desarrollo de tumores digestivos. Evaluación de nuevas estrategias terapéuticas. Búsqueda de nuevos marcadores de Colangiocarcinoma. CIBER. PI: Sandra Pérez Torras. 2015 - 2016
  • Farmacologia Molecular i Teràpies Experimentals (MPET). Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR). PI: Marçal Pastor Anglada.  January 2014 – April 2017
  • Enfermedades Hepáticas y Digestivas. Ministerio de Sanidad y Consumo. PI: Marçal Pastor Anglada. October 2006 – December 2017

Selected publications

  • Grañé-Boladeras N, Spring CM, Hanna WJ, Pastor-Anglada M*, Coe IR. Novel nuclear hENT2 isoforms regulate cell cycle progression via controlling nucleoside transport and nuclear reservoir. Cell Mol Life Sci 2016. 73: 4559-4575. FI: 5,694(Q1)
  • Fernández-Calotti P, Casulleras O, Antolin M, Guarner F, Pastor-Anglada M. Galectin-4 interacts with the drug transporter human concentrative nucleoside transporter 3 to regulate its function.. FASEB J 2016. 30: 544-554. FI: 5,299(Q1)
  • Català A*, Pastor-Anglada M*, Caviedes-Cárdenas L, Malatesta R, Rives S, Vega-García N, Camós M, Fernández-Calotti P. FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799.
  • Pérez-Torras S, Iglesias I, Llopis M, Lozano JJ, Antolín M, Guarner F, Pastor-Anglada M. Transportome Profiling Identifies Profound Alterations in Crohn's Disease Partially Restored by Commensal Bacteria. J Crohns Colitis. 2016 Jul;10(7):850-9. doi: 10.1093/ecco-jcc/jjw042.